周德敏

主要从事药物研发过程中新技术新方法的研究，方向包括新型抗病毒小分子、蛋白质生物大分子药物、药物靶点/生物标志物发现与确证等。

1985–1990 北京医科大学，大学本科
1990–1996 北京医科大学/日本筑波大学，联合培养博士
1996–1998 日本筑波大学应用生物化学系，助理教授
1999–2002 美国加州大学伯克利分校化学系/Scripps研究所博士后
2002–2003 美国Chugai-Roche 制药公司，高级研究员
2003–2008 美国Immusol生物制药公司，创新药物研发部责任人
2008. 10 – 今  北京大学药学院，教授、副院长

国家蛋白质重大研究计划（973）项目首席科学家

天然药物及仿生药物国家重点实验室主任

国家创新药物专项生物候选药牵头科学家

研究经历

2008 – 今                     

食道癌耐放疗基因的发现与确证

基于基因密码子扩展的蛋白质标记新方法

以病毒进入细胞为靶的抗病毒药物研究

2002 – 2008   

基于RNA干扰的功能基因及药物靶标研究平台的研发

丙型肝炎药物筛选体系的建立和药物研发

蛋白药物靶点的克隆、表达及纯化

1990 – 2002   

建立小分子调控蛋白-蛋白相互作用进而控制信号通路的新方法  

核酶定点切割RNA的机理研究

靶向HCV的蛋白酶抑制剂RNA配体体外筛选    

天然物apophine类生物碱的化学全合成

1. Liang S,# Li M,# Yu X, Jin H, Zhang Y, Zhang L, Zhou D, Xiao S.* Synthesis and structure-activity relationship studies of water-soluble β-cyclodextrin-glycyrrhetinic acid conjugates as potential anti-influenza virus agents. Eur. J. Med. Chem. 2019, 166, 328-338
2. Li H,# Li M,# Xu R,# Wang S, Zhang Y, Zhang L, Zhou D,* Xiao S.* Synthesis, structure activity relationship and in vitro anti-influenza virus activity of novel polyphenol-pentacyclic triterpene conjugates. Eur. J. Med. Chem. 2019, 163, 560-568.
3. Jiao P, Wang S, Liang S, Li M, Gao Q, Ji D, Chen Y, Li H, Ran F, Zhang Y, Zhang L, Zhou D,* Xiao S.* Facile preparation and characterization of novel oleanane-type triterpene functionalized β-cyclodextrin conjugates. Chin. Chem. Lett. 2019, 30(3), 690-693.
4. Si L, Meng K, Tian Z, Zhang Z, Soloveva V, Li H, Fu G, Xia Q, Xiao S, Zhang L, Cunningham J. M, Zhou D.* Triterpenoids manipulate a broad range of virus-host fusion via wrapping the HR2 domain prevalentin viral envelopes. Sci. Adv. 2018, 11(4), in press. ( DOI: 10.1126/sciadv.aau8408)
5. Zhang C,* Zhou D.* Chemical modification strategies of viral vectors for gene therapy. Sci China-Chem.; 2018, 48 (11), 1365-1375
6. Li M, Li H, Liang S, Tian Z, Zhou D, Xiao S.* Recent progresses of novel anti-influenza entry inhibitors. Sci. China-Chem.; 2018, 48(11) , 589-599
7. Zhang C*, Zhou X, Yao T, Tian Z, Zhou D*. Precision fluorescent labeling of an adeno-associated virus vector to monitor the viral infection pathway. Biotechnol J.2018, 13(4), e1700374.
8. Zhu X, Xiao S, Zhou D, Sollogoub M, Zhang Y*. Design, synthesis and biological evaluation of water-soluble per-O-methylated cyclodextrin-C60 conjugates as anti-influenza virus agents. Eur. J. Med. Chem.; 2018, 146, 194-205.
9. Xiao S,* Tian Z, Wang Y, Si L, Zhang L, Zhou D.* Recent progress in the antiviral activity and mechanism study of pentacyclic triterpenoids and their derivatives.Med. Res. Rev. 2018, 38(3), 951-976.
10. Wang Y,# Wu X,# Du M, Chen X, Ning X, Chen H, Wang S, Liu J, Liu Z, Li R, Fu G, Wang C, McNutt MA, Zhou D,* Yin Y.* Eg5 inhibitor YL001 induces mitotic arrest and inhibits tumor proliferation. Oncotarget. 2017, 8(26), 42510-42524
11. Meng L, Wang Q, Tang T, Xiao S, Zhang L, Zhou D, Yu F.* Design, synthesis and biological evaluation of pentacyclic triterpene dimers as HCV entry inhibitors.Chin. J. Chem. 2017, 35(8), 1322-1328
12. Wang W, Zhao Z, Zhang Z, Zhang C, Xiao S, Ye X, Zhang L, Xia Q,* Zhou D.* Redirecting Killer T Cells through Incorporation of Azido Sugars for Tethering Ligands. Chembiochem. 2017, 18(21), 2082-2086.