朱健康

朱健康

中国科学院上海生命科学研究院

美国科学院院士

研究方向:

植物逆境生物学、植物表观遗传学、植物定点基因组编辑

学习和工作经历:

2012.4-今, 中国科学院上海植物逆境生物学研究中心,主任
2011.7-至今,中科院上海生命科学研究院 研究员 千人计划
2010-至今, 美国, 普度大学生物化学与园艺及园林系 杰出教授
2009.07-2011.06, 沙特, KAUST大学植物逆境基因组中心 主任
2007-2010, 美国, 加州大学河滨分校植物学与植物科学系 Jane Johnson讲座教授
2004-2006, 美国, 加州大学河滨分校植物学与植物科学系 特聘教授, 研究所所长
2000-2003, 美国, 亚利桑那大学植物科学系 教授
1999-2000, 美国, 亚利桑那大学植物科学系 副教授
1996-1998, 美国, 亚利桑那大学植物科学系 助理教授
1995-1996, 美国, 奥本大学植物与微生物学系 助理教授
1994.6 美国, 洛克菲勒大学 分子生物学 博士后
1990-1993, 美国, 普度大学 植物生理学 获博士学位
1987-1990, 美国, 加州大学河滨分校 植物学 获硕士学位
1983-1987, 中国, 北京农业大学 土壤农业化学 获学士学位
获奖情况
2010年 入选美国科学院院士
2008年 被Thomson Reuters 评为1997-2007年度美国引用率最高的植物学科学家
2005年 获普渡大学农学杰出校友奖
2004年 美国科学促进会会员
2003年 美国植物生物学家学会Charles Albert Shull奖
2002年 亚利桑那大学农业和生命科学学院年度科学家

近期发表论文:
  1. Barajas-Lopez JD, Moreno JR, Gamez-Arjona FM, Pardo JM, Punkkinen M, Zhu JK, Quintero FJ, Fujii H.Upstream kinases of plant SnRKs are involved in salt stress tolerance.Plant J. 2018 Jan;93(1):107-118.
  2. Wang D, Gu J, David R, Wang Z, Yang S, Searle IR, Zhu JK, Timmis JN.Experimental reconstruction of double-stranded break repair-mediated plastid DNA insertion into the tobacco nucleus.Plant J. 2018 Jan;93(2):227-234.
  3. Wang P, Zhao Y, Li Z, Hsu CC, Liu X, Fu L, Hou YJ, Du Y, Xie S, Zhang C, Gao J, Cao M, Huang X, Zhu Y, Tang K, Wang X, Tao WA, Xiong Y, Zhu JK.Reciprocal Regulation of the TOR Kinase and ABA Receptor Balances Plant Growth and Stress Response.Mol Cell. 2018 Jan 4;69(1):100-112
  4. Lu Y, Ye X, Guo R, Huang J, Wang W, Tang J, Tan L, Zhu JK, Chu C, Qian Y.Genome-wide Targeted Mutagenesis in Rice Using the CRISPR/Cas9 System.Mol Plant. 2017 Sep 12;10(9):1242-1245.
  5. Chen IH, Xue L, Hsu CC, Paez JS, Pan L, Andaluz H, Wendt MK, Iliuk AB, Zhu JK, Tao WA.Phosphoproteins in extracellular vesicles as candidate markers for breast cancer.Proc Natl Acad Sci U S A. 2017 Mar 21;114(12):3175-3180.
  6. Gu J, Xia Z, Luo Y, Jiang X, Qian B, Xie H, Zhu JK, Xiong L, Zhu J, Wang ZY.Spliceosomal protein U1A is involved in alternative splicing and salt stress tolerance in Arabidopsis thaliana.Nucleic Acids Res. 2017 Dec 8.
  7. Zou C, Chen A, Xiao L, Muller HM, Ache P, Haberer G, Zhang M, Jia W, Deng P, Huang R, Lang D, Li F, Zhan D, Wu X, Zhang H, Bohm J, Liu R, Shabala S, Hedrich R, Zhu JK, Zhang H.A high-quality genome assembly of quinoa provides insights into the molecular basis of salt bladder-based salinity tolerance and the exceptional nutritional value.Cell Res. 2017 Nov;27(11):1327-1340.
  8. Yang R, Zheng Z, Chen Q, Yang L, Huang H, Miki D, Wu W, Zeng L, Liu J, Zhou JX, Ogas J, Zhu JK, He XJ, Zhang H.The developmental regulator PKL is required to maintain correct DNA methylation patterns at RNA-directed DNA methylation loci.Genome Biol. 2017 May 31;18(1):103.
  9. Xu RH, Wei W, Krawczyk M, Wang W, Luo H, Flagg K, Yi S, Shi W, Quan Q, Li K, Zheng L, Zhang H, Caughey BA, Zhao Q, Hou J, Zhang R, Xu Y, Cai H, Li G, Hou R, Zhong Z, Lin D, Fu X, Zhu J, Duan Y, Yu M, Ying B, Zhang W, Wang J, Zhang E, Zhang C, Li O, Guo R, Carter H, Zhu JK, Hao X, Zhang K.Circulating tumour DNA methylation markers for diagnosis and prognosis of hepatocellular carcinoma.Nat Mater. 2017 Nov;16(11):1155-1161.
  10. Cao MJ, Zhang YL, Liu X, Huang H, Zhou XE, Wang WL, Zeng A, Zhao CZ, Si T, Du J, Wu WW, Wang FX, Xu HE, Zhu JK.Combining chemical and genetic approaches to increase drought resistance in plants.Nat Commun. 2017 Oct 30;8(1):1183.
  11. Mao Y, Botella JR, Zhu JK.Heritability of targeted gene modifications induced by plant-optimized CRISPR systems.Cell Mol Life Sci. 2017 Mar;74(6):1075-1093.
  12. Wang M, Lu Y, Botella JR, Mao Y, Hua K, Zhu JK.Gene Targeting by Homology-Directed Repair in Rice Using a Geminivirus-Based CRISPR/Cas9 System.Mol Plant. 2017 Jul 5;10(7):1007-1010.
  13. Wang D, Qu Z, Yang L, Zhang Q, Liu ZH, Do T, Adelson DL, Wang ZY, Searle I, Zhu JK.Transposable elements (TEs) contribute to stress-related long intergenic noncoding RNAs in plants.Plant J. 2017 Apr;90(1):133-146.
  14. Yan, J., Zhao, C., Zhou, J., Yang, Y., Wang, P., Zhu, X., … Zhu, J.-K. (2016). The miR165/166 Mediated Regulatory Module Plays Critical Roles in ABA Homeostasis and Response in Arabidopsis thaliana. PLoS Genetics, 12(11), e1006416. http://doi.org/10.1371/journal.pgen.1006416
  15. Tang, K., Lang, Z., Zhang, H. & ZHU, J. K. (2016), "The DNA demethylase ROS1 targets genomic regions with distinct chromatin modifications", Nat Plants, Vol. 2 No. 11, pp. 16169.
  16. Yanfei Mao, Zhengjing Zhang, Zhengyan Feng, Pengliang Wei, Hui Zhang, Jose Ramon Botella and Jian-Kang Zhu*(2015).. Development of germ-line-specific CRISPR-Cas9 systems to improve the production of heritable gene modifications in Arabidopsis. plant Biotechnology Journal,doi: 10.1111/pbi.12468.
  17. Yueh-Ju Hou, Yingfang Zhu, Pengcheng Wang, Yang Zhao, Shaojun Xie, Giorgia Batelli, Bangshing Wang, Cheng-Guo Duan, Xingang Wang, Lu Xing, Mingguang Lei, Jun Yan, Xiaohong Zhu, Jian-Kang Zhu*.(2016). Type One Protein Phosphatase 1 and Its Regulatory Protein Inhibitor 2 Negatively Regulate ABA Signaling. PLoS Genetics 12(3): e1005835. doi: 10.1371/journal.pgen.1005835.
  18. Dong-Lei Yang, Guiping Zhang, Kai Tang, Jingwen Li, Lan Yang, Huan Huang, Heng Zhang and Jian-Kang Zhu*.(2015). Dicer-independent RNA-directed DNA methylation in Arabidopsis. Cell Research doi:10.1038/cr.2015.145.
  19. Zhulong Chan*, Yanping Wang, Minjie Cao, Yuehua Gong, Zixin Mu, Haiqing Wang, Yuanlei Hu, Xin Deng, Xin-Jian He, Jian-Kang Zhu*.(2015). RDM4 modulates cold stress resistance in Arabidopsis partially through the CBF-mediated pathway. New Phycologist, doi: 10.1111/nph.13727.
  20. Xiangqiang Zhan, Bilian Qian, Fengqiu Cao, Wenwu Wu, Lan Yang, Qingmei Guan, Xianbin Gu, Pengcheng Wang, Temiloluwa A. Okusolubo, Stephanie L. Dunn, Jian-Kang Zhu & Jianhua Zhu (2015).. An Arabidopsis PWI and RRM motif-containing protein is critical for pre-mRNA splicing and ABA responses. Nature Communications,6:8139.doi:10.1038/ncomms9139.
  21. Hui Zhang, Jinshan Zhang, Pengliang Wei, Botao Zhang, Feng Gou, Zhengyan Feng, Yanfei Mao, Lan Yang, Heng Zhang, Nanfei Xu,* and Jian-Kang Zhu,*. The CRISPR/Cas9 system produces specific and homozygous targeted gene editing in rice in one generation Plant Biotechnology Journal Article first published online: 23 MAY 2014 DOI: 10.1111/pbi.12200.
  22. Chizuko Yamamuro,Daisuke Miki, Zhimin Zheng, Jun Ma, Jing Wang, Zhenbiao Yang, Juan Dong & Jian-Kang Zhu. Overproduction of stomatal lineage cells in Arabidopsis mutants defective in active DNA demethylation Nature Communications. 5, Article number: 4062 doi:10.1038/ncomms5062 Received 03 March 2014 Accepted 07 May 2014 Published 05 June 2014.
  23. Yang Zhao*, Lu Xing*, Xingang Wang, Yueh-Ju Hou, Jinghui Gao, Pengcheng Wang, Cheng-Guo Duan, Xiaohong Zhu, and Jian-Kang Zhu. The ABA Receptor PYL8 Promotes Lateral Root Growth by Enhancing MYB77-Dependent Transcription of Auxin-Responsive Genes Sci. Signal., 3 June 2014 Vol. 7, Issue 328, p. ra53 DOI: 10.1126/scisignal.2005051.
  24. Zhengyan Feng, Yanfei Mao, Nanfei Xu, Botao Zhang, Pengliang Wei, Dong-Lei Yang, Zhen Wang, Zhengjing Zhang, Rui Zheng, Lan Yang, Liang Zeng, Xiaodong Liu, Jian-Kang Zhu. Multigeneration analysis reveals the inheritance, specificity, and patterns of CRISPR/Cas-induced gene modifications in Arabidopsis. Proc Natl Acad Sci U S A. 2014 Feb 18. Doi: 10.1073/pnas.1400822111
  25. Mingguang Lei*, Honggui La*, Kun Lu, Pengcheng Wang, Daisuke Miki, Zhizhong Ren, Cheng-Guo Duan, Xingang Wang, Kai Tang, Liang Zeng, Lan Yang, Heng Zhang, Wenfeng Nie, Pan Liu, Jianping Zhou, Renyi Liu, Yingli Zhong, Dong Liu, Jian-Kang Zhu. Arabidopsis EDM2 promotes IBM1 distal polyadenylation and regulates genome DNA methylation patterns. Proc Natl Acad Sci U S A. 2014 Jan 7;111(1):527-32.