黄强

复旦大学生命科学学院

博士,教授,博士生导师。1991年本科毕业于浙江大学化学系,获学士学位 (化学专业)。分别于1994、1998年在浙大获硕士、博士学位 (物理化学专业)。1999-2000年在柏林洪堡大学生物系分子生物物理专业从事博士后研究。2001-2003年间又两次回到该系及到台湾中山大学化学系继续研究工作。2004年12月进入复旦大学生命科学学院工作,2005年起历任副教授、教授。

研究方向:

遗传工程学:基因编辑系统的结构生物化学与前沿技术;医学遗传学:癌症药物分子设计(小分子、蛋白质或核酸药物);结构生物信息学:生物分子结构与相互作用的理论和模拟。

近期发表论文:

1. C. Huai, G. Li, R. Yao, Y. Zhang, M. Cao, L. Kong, C. Jia, H. Yuan, H. Chen, D. Lu*, Q. Huang*. (2017). Structural insights into DNA cleavage activation of CRISPR-Cas9 system. Nature Communications. 8:1375.

2. H. Yuan, J. Wu, X. Wang, J. Chen, Y. Zhong, Q. Huang*, P. Nan*. (2017). Computational identification of amino-acid mutations that further improve the activity of a chalcone-flavonone isomerase from Glycine max. Frontiers in Plant Science. 8:248.

3. Q. Huang, L. Yu, A. J. Levine, R. Nussinov, B. Ma. (2014). Dipeptide analysis of p53 mutations and evolution of p53 family proteins. Biochimica et Biophysica Acta-Proteins and Proteomics. 1844:198-206.

4. J. Zhu, Q. Yang, D. Dai, Q. Huang*. (2013). X-ray crystal structure of phosphodiesterase 2 in complex with a highly selective, nanomolar inhibitor reveals a binding-induced pocket important for selectivity.Journal of the American Chemical Society. 135: 11708-11711.

5. M. Xu, L. Yu, B. Wan, L. Yu, Q. Huang*. (2011). Predicting inactive conformations of protein kinases using active structures: conformational selection of type-II inhibitors. PLoS One. 6:e22644.

6. C. You#, Q. Huang#, H. Xue, Y. Xu, H. Lu. (2010). Hydrophobic interaction between two cysteines in interior hydrophobic region of protein improves thermostability of a family 11 xylanase from Neocallimastix patriciarumBiotechnology and Bioengineering. 105: 861-870. (# contributed equally)

7. H. Shen, F. Xu, H. Hu, F. Wang, Q. Wu, Q. Huang*, H. Wang*. (2008). Coevolving residues of (beta/alpha)8-barrel proteins play roles in stabilizing active site architecture and coordinating protein dynamics. Journal of Structural Biology. 164: 281-292.

8. Q. Huang, C.- L. Chen, A. Herrmann. (2004). Bilayer conformation of fusion peptide of influenza virus hemagglutinin: a molecular dynamics simulation study. Biophysical Journal. 87:14-22.

9. Q. Huang, S. Ding, C. Y. Hua, H. C. Yang, C. L. Chen. (2004). A computer simulation study of water drying at the interface of protein chains. Journal of Chemical Physics. 121:1969-1977.

10. Q. Huang, R. Opitz, E.-W. Knapp, A. Herrmann. (2002). Protonation and stability of the globular domain of influenza virus hemagglutinin. Biophysical Journal82:1050-1058.